Article

Causal Effects of Corneal Traits on the risk of Keratoconus Using Genetic Instruments

2025-07-17

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> To determine the causal effects of corneal traits on keratoconus (KC) using Mendelian randomization (MR) analysis. <h4>Design</h4> This is a two-sample Mendelian randomization (MR) study. <h4>Methods</h4> We performed two-sample MR analyses using European-ancestry genetic data. Genetic instruments for central corneal thickness (CCT), corneal hysteresis (CH), and corneal resis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 99361bd6-d809-5e7f-a145-7ef8a956efa3
DOI: 10.1101/2025.07.16.25331641

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Causal Effects of Corneal Traits on the risk of Keratoconus Using Genetic InstrumentsDOI 10.1101/2025.07.16.25331641Read

Corneal Biomechanics as a Causal Factor in Myopia and Astigmatism: Evidence from Mendelian RandomizationSemantic proximity Read

Mendelian Randomisation Analysis of Causal Association between Lifestyle, Health Factors, and KeratoconusSemantic proximity Read

Genetic Variants Associated With Corneal Biomechanical Properties and Potentially Conferring Susceptibility to Keratoconus in a Genome-Wide Association StudySemantic proximity Read

Genome-wide association study of corneal biomechanical properties identifies over 200 loci providing insight into the genetic etiology of ocular diseases.Semantic proximity Read

Causal relationship between central corneal thickness and open-angle glaucoma: Evidence from Mendelian randomization.Semantic proximity Read

Central corneal thickness and the risk of primary open-angle glaucoma: a Mendelian randomization mediation analysisSemantic proximity Read

Genetic and immune landscape of keratoconus: insights from Mendelian randomization analysis.Semantic proximity Read

Decoding the Cornea-Glaucoma Association: Evidence From Mendelian Randomization.Semantic proximity Read

Inflammation and keratoconus: A comprehensive bidirectional Mendelian randomization analysis.Semantic proximity Read

Central corneal thickness and the risk of primary open-angle glaucoma: a Mendelian randomisation mediation analysis.Semantic proximity Read

Causal Association Between Atopic Dermatitis and Keratoconus: A Mendelian Randomization Study.Semantic proximity Read

Understanding the role of corneal biomechanics-associated genetic variants by bioinformatic analyses.Semantic proximity Read