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Article

Decoding the Cornea-Glaucoma Association: Evidence From Mendelian Randomization.

Investigative ophthalmology & visual science - 1 Jul 2025

de Vries Victor A, Szabo Anita, Vergroesen Joëlle E, Liu Siyin, van Garderen Karin A, Muthusamy Kirithika, Liskova Petra, Dudakova Lubica, Khawaja Anthony P, Tuft Stephen J, Klaver Caroline C W, Davidson Alice E, Ramdas Wishal D

Abstract excerpt

Purpose: We combined classical association analyses with one-sample and two-sample Mendelian randomization (MR), to comprehensively assess the causal relation among central corneal thickness (CCT), corneal hysteresis, Fuchs endothelial corneal dystrophy (FECD), and open-angle glaucoma (OAG). Methods: We analyzed data from a large population-based cohort study (the Rotterdam Study), an FECD case-control study, and...

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Identifiers

PMID: 40626804
DOI: 10.1167/iovs.66.9.22
PMCID: PMC12248988

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