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Article

Central corneal thickness and the risk of primary open-angle glaucoma: a Mendelian randomisation mediation analysis.

The British journal of ophthalmology - 17 Dec 2024

Katsimpris Andreas, Baumeister Sebastian-Edgar, Baurecht Hansjörg, Tatham Andrew J, Nolde Michael

Abstract excerpt

BACKGROUND: The association of central corneal thickness (CCT) with primary open-angle glaucoma (POAG) remains uncertain. Although several observational studies assessing this relationship have reported an inverse association between CCT and POAG, this could be the result of collider bias. In this study, we leveraged human genetic data to assess through Mendelian randomisation (MR) the effect of CCT on POAG risk...

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Identifiers

PMID: 39117358
DOI: 10.1136/bjo-2023-324996
PMCID: PMC11672028

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