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Genetic and immune landscape of keratoconus: insights from Mendelian randomization analysis.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Sept 2025

Yu Yuhui, Liu Qiang, Zhou Chen, Jiang Juan, Li Yanchun

Abstract excerpt

This study aimed to identify key genes and immune features associated with keratoconus (KC), a progressive eye disorder, by integrating genomic and transcriptomic data using Mendelian randomization (MR) methods. We employed summary data-based Mendelian randomization (SMR) and inverse-variance weighted Mendelian randomization (IVW-MR) to analyze genetic variations from public databases. The study included...

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PMID: 40379964
DOI: 10.1007/s00335-025-10135-x

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