Article
Insufficiency of phosphatidylethanolamine N-methyltransferase is risk for lean non-alcoholic steatohepatitis.
Scientific reports - 17 Feb 2016
Nakatsuka Atsuko, Matsuyama Makoto, Yamaguchi Satoshi, Katayama Akihiro, Eguchi Jun, Murakami Kazutoshi, Teshigawara Sanae, Ogawa Daisuke, Wada Nozomu, Yasunaka Tetsuya, Ikeda Fusao, Takaki Akinobu, Watanabe Eijiro, Wada Jun
Abstract excerpt
Although obesity is undoubtedly major risk for non-alcoholic steatohepatitis (NASH), the presence of lean NASH patients with normal body mass index has been recognized. Here, we report that the insufficiency of phosphatidylethanolamine N-methyltransferase (PEMT) is a risk for the lean NASH. The Pemt-/- mice fed high fat-high sucrose (HFHS) diet were protected from diet-induced obesity and diabetes, while they...
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