Article

E4BP4 in macrophages induces an anti-inflammatory phenotype that ameliorates the severity of colitis

2023-10-12

Abstract excerpt

<title>Abstract</title> <p>Macrophages are versatile cells of the innate immune system that work by altering their pro- or anti-inflammatory features. Their dysregulation leads to inflammatory disorders such as inflammatory bowel disease. We show that macrophage-specific upregulation of the clock output gene and transcription factor E4BP4 reduces the severity of colitis in mice. RNA-sequencing and single-cell ana...

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Literature Corpus work: 99311e8e-bcc5-5816-99fd-6594b0d1c74c
DOI: 10.21203/rs.3.rs-3383296/v1

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