E4BP4 in macrophages induces an anti-inflammatory phenotype that ameliorates the severity of colitis.

Abstract excerpt

Macrophages are versatile cells of the innate immune system that work by altering their pro- or anti-inflammatory features. Their dysregulation leads to inflammatory disorders such as inflammatory bowel disease. We show that macrophage-specific upregulation of the clock output gene and transcription factor E4BP4 reduces the severity of colitis in mice. RNA-sequencing and single-cell analyses of macrophages...

Topics

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• Macrophages
• Basic-Leucine Zipper Transcription Factors
• Colitis
• Disease Models, Animal
• Inflammation