Article
The periphery and the core properties explain the omnigenic model in the human interactome
2019-08-29
Abstract excerpt
Understanding the connectivity patterns of genes in a localized disease neighborhood or disease module in a molecular interaction network (interactome) is a key step toward advancing the knowledge about molecular mechanisms underlying a complex disease. In this work, we introduce a framework that detects peripheral and core regions of a disease in the human interactome. We leverage gene expression data on 104 di...
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Identifiers and source
- Literature Corpus work
- 992b1ef4-93d7-5334-9756-5dd7d685d469
- DOI
- 10.1101/749358