Article
Disease networks. Uncovering disease-disease relationships through the incomplete interactome.
Science (New York, N.Y.) - 20 Feb 2015
Menche Jörg, Sharma Amitabh, Kitsak Maksim, Ghiassian Susan Dina, Vidal Marc, Loscalzo Joseph, Barabási Albert-László
Abstract excerpt
According to the disease module hypothesis, the cellular components associated with a disease segregate in the same neighborhood of the human interactome, the map of biologically relevant molecular interactions. Yet, given the incompleteness of the interactome and the limited knowledge of disease-associated genes, it is not obvious if the available data have sufficient coverage to map out modules associated with...
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