Article

C3: Connect separate Connected Components to form a succinct disease module

2020-06-07

Abstract excerpt

Accurate disease module is helpful in understanding the molecular mechanism of disease causation and identifying drug target. However, for the fragmentization of disease module in incomplete human interactome, how to determine connectivity pattern and detect a full neighbourhood of disease is an open problem. In this paper, a topology-based method is developed to dissect the connectivity of intermediate nodes and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a46e8b05-5ac4-51c1-8822-c087296ee63a
DOI: 10.1101/2020.06.05.137398

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

C3: Connect separate Connected Components to form a succinct disease moduleDOI 10.1101/2020.06.05.137398Read

DiseaseConnect: a comprehensive web server for mechanism-based disease-disease connections.Semantic proximity Read

Disease networks. Uncovering disease-disease relationships through the incomplete interactome.Semantic proximity Read

The periphery and the core properties explain the omnigenic model in the human interactomeSemantic proximity Read

Disease networks and their contribution to disease understanding and drug repurposing: Evolution of the concept, techniques and data sourcesSemantic proximity Read

A systems approach to refine disease taxonomy by integrating phenotypic and molecular networksSemantic proximity Read

A Systems Approach to Refine Disease Taxonomy by Integrating Phenotypic and Molecular Networks.Semantic proximity Read

LAMP: disease classification derived from layered assessment on modules and pathways in the human gene networkSemantic proximity Read

The expanded human disease network combining protein-protein interaction information.Semantic proximity Read

Human symptoms-disease network.Semantic proximity Read

Graphical Features of Functional Genes in Human Protein Interaction Network.Semantic proximity Read

The human disease network.Semantic proximity Read

Getting connected: analysis and principles of biological networks.Semantic proximity Read