Article

A single, improbable B cell receptor mutation confers potent neutralization against cytomegalovirus

2022-01-21

Abstract excerpt

Cytomegalovirus (CMV) is a leading cause of infant hearing loss and neurodevelopmental delay, but vaccine candidates have faced challenges eliciting neutralizing antibodies. One of the most well-studied targets for CMV vaccines is the viral fusogen glycoprotein B (gB), which is required for viral entry into host cells. Within gB, antigenic domain 2 site 1 (AD-2S1) is a target of potently neutralizing antibodies, b...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 99056e3b-c99b-55f6-8142-497ae02fc8b8
DOI: 10.1101/2022.01.19.476974

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A single, improbable B cell receptor mutation confers potent neutralization against cytomegalovirusDOI 10.1101/2022.01.19.476974Read

A single, improbable B cell receptor mutation confers potent neutralization against cytomegalovirus.Semantic proximity Read

Crystal Structure of the Human Cytomegalovirus Glycoprotein BSemantic proximity Read

Structural Basis for the Recognition of Human Cytomegalovirus Glycoprotein B by a Neutralizing Human AntibodySemantic proximity Read

Specificity and effector functions of non-neutralizing gB-specific monoclonal antibodies isolated from healthy individuals with human cytomegalovirus infectionSemantic proximity Read

Vaccination with a disabled infectious single cycle cytomegalovirus vaccine elicits a distinct glycoprotein B-specific monoclonal antibody repertoire compared to that of naturally-infected individualsSemantic proximity Read

AI recognizes convergent somatic hypermutation signatures to allow the discovery of variant-resilient broadly neutralizing antibodiesSemantic proximity Read

Functional dissection of HCMV gB's autonomous fusion activity provides insights into how polymorphisms in clinical isolates confer distinct characteristics.Semantic proximity Read

Antibody binding to native cytomegalovirus glycoprotein B predicts efficacy of the gB/MF59 vaccine in humansSemantic proximity Read

Contribution of rare mutational outcomes to broadly neutralizing antibodies.Semantic proximity Read

De novo identification of VRC01 class HIV-1-neutralizing antibodies by next-generation sequencing of B-cell transcripts.Semantic proximity Read

Functional Improbable Antibody Mutations Critical for HIV Broadly Neutralizing Antibody DevelopmentSemantic proximity Read

Vaccine genetics of IGHV1-2 VRC01-class broadly neutralizing antibody precursor naïve human B cellsSemantic proximity Read