Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A single, improbable B cell receptor mutation confers potent neutralization against cytomegalovirus.

PLoS pathogens - 1 Jan 2023

Jenks Jennifer A, Amin Sharmi, Sponholtz Madeline R, Kumar Amit, Wrapp Daniel, Venkatayogi Sravani, Tu Joshua J, Karthigeyan Krithika, Valencia Sarah M, Connors Megan, Harnois Melissa J, Hora Bhavna, Rochat Eric, McLellan Jason S, Wiehe Kevin, Permar Sallie R

Abstract excerpt

Cytomegalovirus (CMV) is a leading cause of infant hearing loss and neurodevelopmental delay, but there are no clinically licensed vaccines to prevent infection, in part due to challenges eliciting neutralizing antibodies. One of the most well-studied targets for CMV vaccines is the viral fusogen glycoprotein B (gB), which is required for viral entry into host cells. Within gB, antigenic domain 2 site 1 (AD-2S1)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Neutralizing
Share to Antibodies, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytomegalovirus

Share to Cytomegalovirus Infections

Share to Mutation

Share to Receptors, Antigen, B-Cell

Share to Viral Envelope Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 36662906
DOI: 10.1371/journal.ppat.1011107
PMCID: PMC9891502

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A single, improbable B cell receptor mutation confers potent neutralization against cytomegalovirus.PMID 36662906Read ↗

A single, improbable B cell receptor mutation confers potent neutralization against cytomegalovirusSemantic proximity Read ↗

Crystal Structure of the Human Cytomegalovirus Glycoprotein BSemantic proximity Read ↗

Specificity and effector functions of non-neutralizing gB-specific monoclonal antibodies isolated from healthy individuals with human cytomegalovirus infectionSemantic proximity Read ↗

Structural Basis for the Recognition of Human Cytomegalovirus Glycoprotein B by a Neutralizing Human AntibodySemantic proximity Read ↗

Functional dissection of HCMV gB's autonomous fusion activity provides insights into how polymorphisms in clinical isolates confer distinct characteristics.Semantic proximity Read ↗

Antibody binding to native cytomegalovirus glycoprotein B predicts efficacy of the gB/MF59 vaccine in humansSemantic proximity Read ↗

De novo identification of VRC01 class HIV-1-neutralizing antibodies by next-generation sequencing of B-cell transcripts.Semantic proximity Read ↗

Vaccination with a disabled infectious single cycle cytomegalovirus vaccine elicits a distinct glycoprotein B-specific monoclonal antibody repertoire compared to that of naturally-infected individualsSemantic proximity Read ↗

Contribution of rare mutational outcomes to broadly neutralizing antibodies.Semantic proximity Read ↗

B cell repertoire sequencing of HIV-1 pediatric elite-neutralizers identifies multiple broadly neutralizing antibody clonotypesSemantic proximity Read ↗

Functional Improbable Antibody Mutations Critical for HIV Broadly Neutralizing Antibody DevelopmentSemantic proximity Read ↗

Germline V‐genes sculpt the binding site of a family of antibodies neutralizing human cytomegalovirusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.