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Article

Crystal Structure of the Human Cytomegalovirus Glycoprotein B

20 Oct 2015

Abstract excerpt

Human cytomegalovirus (HCMV), a dsDNA, enveloped virus, is a ubiquitous pathogen that establishes lifelong latent infections and caused disease in persons with compromised immune systems, e.g., organ transplant recipients or AIDS patients. HCMV is also a leading cause of congenital viral infections in newborns. Entry of HCMV into cells requires the conserved glycoprotein B (gB), thought to function as a fusogen...

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PMID: 26484870
DOI: 10.1371/journal.ppat.1005227

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