Cas9-Mediated Knockout of Ndrg2 Enhances the Regenerative Potential of Dendritic Cells for Wound Healing

Abstract excerpt

<title>Abstract</title> <p>Chronic wounds impose a significant healthcare burden to a broad patient population. Cell based therapies, while having shown benefits for the treatment of chronic wounds, have not achieved widespread adoption into clinical practice. Here, we developed a novel CRISPR/Cas9 approach to precisely edit dendritic cells (DCs) to enhance their therapeutic potential for healing chronic wounds....

Topics

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• Animals, Genetically Modified
• CAR-T cell therapy research
• CRISPR and Genetic Engineering
• CRISPR-Cas Systems
• Gene Transfer Techniques
• Genetic Vectors
• Keratinocytes
• RNA Interference and Gene Delivery

Identifiers and source

Literature Corpus work

98f7d8c0-e9ca-5662-bff5-a949a00f7022

DOI

10.21203/rs.3.rs-1781479/v1