Cas9-Mediated Knockout of Ndrg2 Enhances the Regenerative Potential of Dendritic Cells for Wound Healing

Abstract excerpt

Chronic wounds impose a significant healthcare burden to a broad patient population. Cell based therapies, while having shown benefits for the treatment of chronic wounds, have not achieved widespread adoption into clinical practice. Here, we developed a novel CRISPR/Cas9 approach to precisely edit dendritic cells (DCs) to enhance their therapeutic potential for healing chronic wounds. Using single-cell RNA sequen...

Topics

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• CAR-T cell therapy research
• Clustered Regularly Interspaced Short Palindromic Repeats
• CRISPR and Genetic Engineering
• CRISPR-Associated Protein 9
• CRISPR-Cas Systems
• Dendritic Cells
• Gene Editing
• RNA Interference and Gene Delivery

Identifiers and source

Literature Corpus work

0354aac8-5d06-5338-8df7-1d5cfab61de3

DOI

10.1101/2022.03.14.484360