Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Microneedle-assisted genome editing: A transdermal strategy of targeting NLRP3 by CRISPR-Cas9 for synergistic therapy of inflammatory skin disorders

10 Mar 2021

Abstract excerpt

and dexamethasone (Dex)-containing polymeric nanoparticles. Upon insertion into the skin, the MN can be dissolved quickly to release two types of nanoformulations, which are subsequently internalized by keratinocytes and surrounding immune cells to exert their therapeutic effects in the inflammatory subcutaneous layers. Thus, the MN-enabled transdermal codelivery of Cas9 RNP nanocomplexes and Dex nanoparticles...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advancements in Transdermal Drug Delivery
Share to Dermatology and Skin Diseases
Share to Transgenic Plants and Applications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33692106
DOI: 10.1126/sciadv.abe2888

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Microneedle-assisted genome editing: A transdermal strategy of targeting NLRP3 by CRISPR-Cas9 for synergistic therapy of inflammatory skin disordersPMID 33692106Read ↗

Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseasesSemantic proximity Read ↗

Microneedle Technologies for Drug Delivery: Innovations, Applications, and Commercial ChallengesSemantic proximity Read ↗

Research Techniques Made Simple: Delivery of the CRISPR/Cas9 Components into Epidermal Cells.Semantic proximity Read ↗

Topical Application of Mesenchymal Stem Cell Exosomes Alleviates the Imiquimod Induced Psoriasis-Like Inflammation.Semantic proximity Read ↗

A comprehensive review of the medical and cosmetic applications of exosomes in dermatologySemantic proximity Read ↗

Novel nanosome delivery system combined with siRNA targeting the antimicrobial gene DFB4: a new approach for psoriasis management?Semantic proximity Read ↗

Cas9-mediated knockout of Ndrg2 enhances the regenerative potential of dendritic cells for wound healingSemantic proximity Read ↗

Cas9-Mediated Knockout of Ndrg2 Enhances the Regenerative Potential of Dendritic Cells for Wound HealingSemantic proximity Read ↗

Genome editing of PAR2 through targeted delivery of CRISPR-Cas9 system for alleviating acute lung inflammation via ERK/NLRP3/IL-1β and NO/iNOS signallingSemantic proximity Read ↗

Microneedle-mediated vaccine delivery: harnessing cutaneous immunobiology to improve efficacy.Semantic proximity Read ↗

Comprehensive molecular characterization of microneedling therapy in a human three‐dimensional skin modelSemantic proximity Read ↗

Nanotechnology-Based Topical Delivery of Natural Products for the Management of Atopic DermatitisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.