Article

Topical application of Cas9 ribonucleoproteins inhibits corneal neovascularization in a mouse model of alkali burn injury

2025-07-25

Abstract excerpt

<title>Abstract</title> <p> Corneal neovascularization is a sight-threatening condition for which current treatments such as anti-VEGF agents are limited by invasiveness and side effects. We present the first non-viral, CRISPR/Cas9-based gene therapy delivered via topical eye drops that penetrates the cornea and inhibits pathological neovascularization. Cas9 ribonucleoproteins (RNPs) targeting the <italic>Vegfa...

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Identifiers and source

Literature Corpus work: 3bbb56b5-2304-55bc-be8a-0125a9b7dd1b
DOI: 10.21203/rs.3.rs-7096816/v1

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