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SOX2 Activation Using CRISPR/dCas9 Promotes Wound Healing in Corneal Endothelial Cells

1 Oct 2018

Abstract excerpt

There are no effective treatments for corneal endothelial diseases, except for corneal transplantation, as human corneal endothelial cells (hCECs) do not regenerate. The regeneration of hCECs could be induced through regulation of the expression of specific genes. In this study, we investigated whether the overexpression of sex-determining region Y-box 2 (SOX2) can regenerate hCECs in vivo and in vitro. SOX2 was...

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PMID: 30270540
DOI: 10.1002/stem.2915

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