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Kidney-specific methylation patterns correlate with kidney function and are lost upon kidney disease progression

12 Feb 2024

Abstract excerpt

BACKGROUND: Chronological and biological age correlate with DNA methylation levels at specific sites in the genome. Linear combinations of multiple methylation sites, termed epigenetic clocks, can inform us the chronological age and predict multiple health-related outcomes. However, why some sites correlating with lifespan, healthspan, or specific medical conditions remain poorly understood. Kidney fibrosis is...

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PMID: 38347603
DOI: 10.1186/s13148-024-01642-w

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