Article

Transposase-Assisted Tagmentation: An Economical and Scalable Strategy for Single-Worm Whole-Genome Sequencing

2023-12-21

Abstract excerpt

AlphaMissense identifies 23 million human missense variants as likely pathogenic, but only 0.1% have been clinically classified. To experimentally validate these predictions, chemical mutagenesis presents a rapid, cost-effective method to produce billions of mutations in model organisms. However, the prohibitive costs and limitations in the throughput of whole-genome sequencing (WGS) technologies, crucial for vari...

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Literature Corpus work: 98ce9027-dcff-5a5e-826a-06f707c1c7b7
DOI: 10.1101/2023.12.21.572713

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