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Article

Accelerating Gene Discovery by Phenotyping Whole-Genome Sequenced Multi-mutation Strains and Using the Sequence Kernel Association Test (SKAT).

PLoS genetics - 1 Aug 2016

Timbers Tiffany A, Garland Stephanie J, Mohan Swetha, Flibotte Stephane, Edgley Mark, Muncaster Quintin, Au Vinci, Li-Leger Erica, Rosell Federico I, Cai Jerry, Rademakers Suzanne, Jansen Gert, Moerman Donald G, Leroux Michel R

Abstract excerpt

Forward genetic screens represent powerful, unbiased approaches to uncover novel components in any biological process. Such screens suffer from a major bottleneck, however, namely the cloning of corresponding genes causing the phenotypic variation. Reverse genetic screens have been employed as a way to circumvent this issue, but can often be limited in scope. Here we demonstrate an innovative approach to gene...

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PMID: 27508411
DOI: 10.1371/journal.pgen.1006235
PMCID: PMC4980031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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