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TaoChongBao: A Large-Scale <i>Caenorhabditis elegans</i> Mutagenesis and Missense Variant Database Bridging Worm and Human Genomes

2025-12-09

Abstract excerpt

We generated and sequenced 12,069 viable Caenorhabditis elegans strains produced by ethyl methanesulfonate mutagenesis, identifying 20,315,536 variants, including 541,102 unique missense mutations across 20,914 genes. To organize and visualize this resource, we developed TaoChongBao, an open-access database and strain repository that integrates C. elegans mutation data with AlphaMissense-predicted pathogenicity...

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Literature Corpus work
7a2b6821-220e-5f59-86d9-4df4cf4a88ee
DOI
10.64898/2025.12.03.692224
Open publication

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TaoChongBao: A Large-Scale <i>Caenorhabditis elegans</i> Mutagenesis and Missense Variant Database Bridging Worm and Human GenomesDOI 10.64898/2025.12.03.692224
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