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Article

Whole-genome profiling of mutagenesis in Caenorhabditis elegans.

Genetics - 1 Jun 2010

Flibotte Stephane, Edgley Mark L, Chaudhry Iasha, Taylor Jon, Neil Sarah E, Rogula Aleksandra, Zapf Rick, Hirst Martin, Butterfield Yaron, Jones Steven J, Marra Marco A, Barstead Robert J, Moerman Donald G

Abstract excerpt

Deep sequencing offers an unprecedented view of an organism's genome. We describe the spectrum of mutations induced by three commonly used mutagens: ethyl methanesulfonate (EMS), N-ethyl-N-nitrosourea (ENU), and ultraviolet trimethylpsoralen (UV/TMP) in the nematode Caenorhabditis elegans. Our analysis confirms the strong GC to AT transition bias of EMS. We found that ENU mainly produces A to T and T to A...

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Identifiers

PMID: 20439774
DOI: 10.1534/genetics.110.116616
PMCID: PMC2881127

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