Article

Accelerating Gene Discovery by Phenotyping Whole-Genome Sequenced Multi-Mutation Strains and Using the Sequence Kernel Association Test (SKAT)

2015-09-24

Abstract excerpt

Forward genetic screens represent powerful, unbiased approaches to uncover novel components in any biological process. Such screens suffer from a major bottleneck, however, namely the cloning of corresponding genes causing the phenotypic variation. Reverse genetic screens have been employed as a way to circumvent this issue, but can often be limited in scope. Here we demonstrate an innovative approach to gene disc...

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Literature Corpus work: ac8d35b9-d7d1-5484-9111-7cafa0b1df5c
DOI: 10.1101/027540

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