Article
Mutation Mapping and Identification by Whole-Genome Sequencing.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2022
Smith Harold E
Abstract excerpt
Geneticists approach biology with a simple question: which genes are required for the pathway or process of interest? Classical genetic screens (aka forward genetics) in model organisms such as Caenorhabditis elegans have been the method of choice for answering that question. Next-generation sequencing provides the means to generate a comprehensive list of sequence variants, including the mutation of interest....
Topics
- Animals
- Caenorhabditis elegans
- DNA Mutational Analysis
- High-Throughput Nucleotide Sequencing
- Mutation
- Whole Genome Sequencing