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TaoChongBao: a large-scale C. elegans missense variant database bridging worm and human genomes.

Life science alliance - 1 Jun 2026

Li Ming, Wang Shimin, Chai Yongping, Guo Zhengyang, Wang Zi, Chen Zhe, Lei Kexin, Ke Jingyi, Huang Xingshen, Chen Guanghan, Huang Peng, Xu Kaiming, Shen Zijie, Li Wei, Ou Guangshuo

Abstract excerpt

We generated and sequenced 12,069 viable Caenorhabditis elegans strains produced by ethyl methanesulfonate mutagenesis, identifying 20,315,536 variants, including 541,102 unique missense mutations across 20,914 genes. Most strains exhibit resistance to the anti-nematode drug ivermectin, whereas some others display phenotypes like dumpy morphology, uncoordinated movement, multivulva formation, and blistered...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41876123
DOI: 10.26508/lsa.202603631
PMCID: PMC13009681

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