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Article

Synemin Redefined: Multiple Binding Partners Results in Multifunctionality

17 Mar 2020

Abstract excerpt

Historically synemin has been studied as an intermediate filament protein. However, synemin also binds the type II regulatory (R) subunit α of protein kinase A (PKA) and protein phosphatase type 2A, thus participating in the PKA and phosphoinositide 3-kinase (PI3K)-Akt and signaling pathways. In addition, recent studies using transgenic mice indicate that a significant function of synemin is its role in signaling...

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Identifiers

PMID: 32258037
DOI: 10.3389/fcell.2020.00159

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