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Article

Multiomics Insights Into the Role of Spondin-1 in the Pathogenesis and Prognosis of Atrial Fibrillation.

Journal of the American Heart Association - 7 Jul 2026

Long Xianglin, Zhang Yeshen, Gao Xinyue, Chen Hao, Li Yunshu, Xiong Weiwu, Wang Xiaoyan, Zhang Zhihui

Abstract excerpt

BACKGROUND: Atrial fibrillation (AF) is characterized by progressive structural remodeling, yet molecular drivers remain incompletely understood. This study aimed to identify novel protein targets for AF using an integrative multiomics approach. METHODS: We performed a multilayered genetic screen combining Mendelian randomization and colocalization analyses of plasma protein (protein quantitative trait loci) and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42333675
DOI: 10.1161/JAHA.126.050152
PMCID: PMC13477379

Genes

SPON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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