Article

Pregnenolone reorganizes cytoskeleton to promote neuron development via CLIP1

2022-08-03

Abstract excerpt

Pregnenolone (P5) is a neurosteroid produced in the brain. It improves cognitive function and protects against cannabis intoxication as well as spinal cord injury. P5 activates CLIP1, which helps microtubule polymerization at its growing end; however, the significance of P5 activation of CLIP1 in the brain is still unknown. Here we examined the roles of P5 in cultured neurons and in zebrafish cerebellum. We show t...

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Literature Corpus work: 98ba950a-82f9-5b0f-ad77-b25a18db8ae8
DOI: 10.1101/2022.08.01.502406

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