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Article

Impaired neural differentiation and glymphatic CSF flow in the Ccdc39 rat model of neonatal hydrocephalus: genetic interaction with L1cam.

Disease models & mechanisms - 21 Nov 2019

Emmert A Scott, Iwasawa Eri, Shula Crystal, Schultz Preston, Lindquist Diana, Dunn R Scott, Fugate Elizabeth M, Hu Yueh-Chiang, Mangano Francesco T, Goto June

Abstract excerpt

Neonatal hydrocephalus affects about one child per 1000 births and is a major congenital brain abnormality. We previously discovered a gene mutation within the coiled-coil domain-containing 39 (Ccdc39) gene, which causes the progressive hydrocephalus (prh) phenotype in mice due to lack of ependymal-cilia-mediated cerebrospinal fluid (CSF) flow. In this study, we used CRISPR/Cas9 to introduce the Ccdc39 gene...

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Identifiers

PMID: 31771992
DOI: 10.1242/dmm.040972
PMCID: PMC6898999

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