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Article

Requirement of Npc1 and availability of cholesterol for early embryonic cell movements in zebrafish

17 May 2011

Abstract excerpt

Niemann-Pick disease, type C (NP-C), often associated with Niemann-Pick disease, type C1 (NPC1) mutations, is a cholesterol-storage disorder characterized by cellular lipid accumulation, neurodegeneration, and reduced steroid production. To study NPC1 function in vivo, we cloned zebrafish npc1 and analyzed its gene expression and activity by reducing Npc1 protein with morpholino (MO)-oligonucleotides. Filipin...

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PMID: 21576600
DOI: 10.1194/jlr.m012377

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