Article

Inositol Polyphosphate-5-phosphatase K ( <i>Inpp5k</i> ) enhances sprouting of corticospinal tract axons after CNS trauma

2021-04-28

Abstract excerpt

<h4>ABSTRACT</h4> Failure of CNS neurons to mount a significant intrinsic growth response after trauma results in chronic functional deficits after spinal cord injury. Approaches to identify novel axon growth activators include transcriptional and repressor screening of embryonic cortical and retinal ganglion neurons in vitro . These high throughput approaches have identified several candidates; however, their i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5bb0af77-1004-5094-b2ea-3f0170d4f74f
DOI: 10.1101/2021.04.27.441184

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inositol Polyphosphate-5-phosphatase K ( <i>Inpp5k</i> ) enhances sprouting of corticospinal tract axons after CNS traumaDOI 10.1101/2021.04.27.441184Read

PATZ1 Reinstates a Growth-Permissive Chromatin Landscape in Adult Corticospinal Neurons After InjurySemantic proximity Read

Overexpressing eukaryotic elongation factor 1 alpha (eEF1A) proteins to promote corticospinal axon repair after injurySemantic proximity Read

C-terminal domain small phosphatase 1 (CTDSP1) regulates growth factor expression and axonal regenerationSemantic proximity Read

The Application of Omics Technologies to Study Axon Regeneration and CNS RepairSemantic proximity Read

KLF6 and STAT3 co-occupy regulatory DNA and functionally synergize to promote axon growth in CNS neuronsSemantic proximity Read

Mitf is a Schwann Cell Sensor of Axonal Integrity that Drives Nerve RepairSemantic proximity Read

Pregnenolone reorganizes cytoskeleton to promote neuron development via CLIP1Semantic proximity Read

RNAseq dataset describing transcriptional changes in cervical sensory ganglia after bilateral pyramidotomy and forelimb intramuscular gene therapy with AAV1 encoding human neurotrophin-3Semantic proximity Read

Widespread AAV-mediated CSPG digestion impairs functional recovery after cervical spinal cord injurySemantic proximity Read

Protein phosphatase 2A (PP2A) activation promotes axonal growth and recovery in the CNS.Semantic proximity Read

Probing regenerative heterogeneity of corticospinal neurons with scRNA-SeqSemantic proximity Read

Peripheral nervous system genes expressed in central neurons induce growth on inhibitory substrates.Semantic proximity Read