Article

CDKL5’s role in microtubule-based transport and cognitive function

2024-08-29

Abstract excerpt

Cyclin-dependent kinase like 5 (CDKL5) is a serine-threonine kinase highly enriched in mammalian neurons. CDKL5 is located on the X-chromosome and its loss-of-function leads to a severe neurodevelopmental disorder called CDKL5 deficiency disorder (CDD). CDKL5 phosphorylates microtubule-associated protein MAP1S and regulates its binding to microtubules. How MAP1S phosphorylation affects microtubule function is not...

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Literature Corpus work: c23dad9b-4263-59ec-b59b-b69177a2e078
DOI: 10.1101/2024.08.28.610038

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