Article
Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-κB signaling.
Neuron - 6 Oct 2010
Li Jianxue, Gu Xuesong, Ma Yinghua, Calicchio Monica L, Kong Dong, Teng Yang D, Yu Lili, Crain Andrew M, Vartanian Timothy K, Pasqualini Renata, Arap Wadih, Libermann Towia A, Snyder Evan Y, Sidman Richard L
Abstract excerpt
The molecular pathways controlling cerebellar Purkinje cell dendrite formation and maturation are poorly understood. The Purkinje cell degeneration (pcd) mutant mouse is characterized by mutations in Nna1, a gene discovered in an axonal regenerative context, but whose actual function in development and disease is unknown. We found abnormal development of Purkinje cell dendrites in postnatal pcd(Sid) mice and...
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