Article

Loss of Dynein Axonemal Heavy Chain 5 Causes Cortical Development Disorders and CSF Flow Stagnation

2024-02-01

Abstract excerpt

<h4>Background: </h4> Dynein axonemal heavy chain 5 (Dnah5) has been identified as a key gene associated with primary ciliary dyskinesia in humans. Studies have demonstrated that mice lacking Dnah5 (Dnah5-/-) develop acute hydrocephalus shortly after birth due to impaired ciliary motility, resulting in cerebrospinal fluid (CSF) stagnation and ultimately death within approximately a month. Notably, such hydrocephal...

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Literature Corpus work: 109513b1-e2f8-5481-8e72-b224167a0ee2
DOI: 10.21203/rs.3.rs-3882997/v1

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