Article

Leukocyte DNA methylation in Alzheimer´s disease associated genes: replication of findings from neuronal cells

2022-03-24

Abstract excerpt

Differences in gene-wide DNA methylation of the Alzheimer’s disease (AD) associated genes BIN1 , HLA-DRB5, SORL1 , SLC24A4 , and ABCA7 are reported to be associated with AD in post-mortem brain samples. We investigated whether the same associations could be found in leukocytes collected pre-mortem. Using cohort data of 544 Swedish twins (204 dementia diagnoses), we replicated the findings in HLA-DRB5 and SLC24A4 a...

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Literature Corpus work: 98aebc84-8b1a-50f3-8c1d-9633f4b128cd
DOI: 10.21203/rs.3.rs-1479093/v1

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