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Article

Exploring novel blood-based DNA methylation biomarkers for alzheimer's disease via targeted sequencing of highly variable CpG sites.

BMC research notes - 12 Aug 2025

Ohmomo Hideki, Komaki Shohei, Minabe Shiori, Sutoh Yoichi, Otsuka-Yamasaki Yayoi, Sasaki Makoto, Shimizu Atsushi

Abstract excerpt

OBJECTIVE: Dementia, particularly Alzheimer’s disease (AD), continues to be a major public health concern due to population aging, yet minimally invasive biomarkers for early diagnosis have not been established. DNA methylation (DNAm) has recently attracted considerable attention as a promising biomarker. This study aimed to identify blood-based DNAm biomarkers for early detection of AD. RESULTS: We analysed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40796861
DOI: 10.1186/s13104-025-07417-7
PMCID: PMC12341124

Genes

APOE
CADM1
EXOC2
TUBA1B

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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