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Association of Brain DNA Methylation in<i>SORL1</i>,<i>ABCA7</i>,<i>HLA-DRB5</i>,<i>SLC24A4</i>, and<i>BIN1</i>With Pathological Diagnosis of Alzheimer Disease

3 Nov 2014

Abstract excerpt

IMPORTANCE: Recent large-scale genome-wide association studies have discovered several genetic variants associated with Alzheimer disease (AD); however, the extent to which DNA methylation in these AD loci contributes to the disease susceptibility remains unknown. OBJECTIVE: To examine the association of brain DNA methylation in 28 reported AD loci with AD pathologies. DESIGN, SETTING, AND PARTICIPANTS: Ongoing...

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PMID: 25365775
DOI: 10.1001/jamaneurol.2014.3049

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