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Article

CARD8 inflammasome activation triggers pyroptosis in human T cells

25 Aug 2020

Abstract excerpt

Inflammasomes execute a unique type of cell death known as pyroptosis. Mostly characterized in myeloid cells, caspase-1 activation downstream of an inflammasome sensor results in the cleavage and activation of gasdermin D (GSDMD), which then forms a lytic pore in the plasma membrane. Recently, CARD8 was identified as a novel inflammasome sensor that triggers pyroptosis in myeloid leukemia cells upon inhibition of...

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PMID: 32840892
DOI: 10.15252/embj.2020105071

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