Article

NLRP1 variants affect B cells sensitivity to DPP9 inhibition

2024-05-21

Abstract excerpt

<title>Abstract</title> <p>Inflammasome genetics affect several multifactorial diseases' development and severity, but the exact mechanism and cell types involved are mainly unknown. Recent findings have demonstrated the activation of caspase-1 and the release of IL-1β in B lymphocytes, leading us to hypothesize that genetic variants within the inflammasome may influence B cell functions and contribute to patholo...

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Literature Corpus work: 745c31c1-27ef-5783-8e64-3c60ff085249
DOI: 10.21203/rs.3.rs-4331359/v1

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