Article

CARD8 negatively regulates NLRP1 inflammasome activation level by interaction with NLRP1

2022-06-28

Abstract excerpt

NLRP1 inflammasome functions as canonical cytosolic sensor in response to intracellular infections and is implicated in auto-inflammatory diseases. But the regulation and signal transduction mechanisms of NLRP1 are incompletely understood. Here, we show that the T60 variant of CARD8, but not the canonical T48 isoform, negatively regulates NLRP1 inflammasome activation by directly interacting with the receptor mole...

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Literature Corpus work: 4b133b0d-3ad0-5bcf-9ea5-0ff9a09deb9e
DOI: 10.1101/2022.06.26.497666

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