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Article

DPP9 directly sequesters the NLRP1 C-terminus to repress inflammasome activation

2020-08-14

Abstract excerpt

NLRP1 is a cytosolic inflammasome sensor that mediates activation of caspase-1, which in turn induces cytokine maturation and pyroptotic cell death 1-6 . Gain-of-function NLPR1 mutations cause skin inflammatory diseases including carcinoma, keratosis, and papillomatosis 7-14 . NLRP1 contains a unique function-to-find domain (FIIND) that autoproteolyzes into noncovalently associated subdomains 15-18 . Proteasoma...

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Identifiers and source

Literature Corpus work
e2d5688e-fe63-5a74-bd31-789f8a32b0d8
DOI
10.1101/2020.08.14.246132
Open publication

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DPP9 directly sequesters the NLRP1 C-terminus to repress inflammasome activationDOI 10.1101/2020.08.14.246132
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