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Article

A Powerful Approach to Estimating Annotation-Stratified Genetic Covariance via GWAS Summary Statistics.

American journal of human genetics - 7 Dec 2017

Lu Qiongshi, Li Boyang, Ou Derek, Erlendsdottir Margret, Powles Ryan L, Jiang Tony, Hu Yiming, Chang David, Jin Chentian, Dai Wei, He Qidu, Liu Zefeng, Mukherjee Shubhabrata, Crane Paul K, Zhao Hongyu

Abstract excerpt

Despite the success of large-scale genome-wide association studies (GWASs) on complex traits, our understanding of their genetic architecture is far from complete. Jointly modeling multiple traits' genetic profiles has provided insights into the shared genetic basis of many complex traits. However, large-scale inference sets a high bar for both statistical power and biological interpretability. Here we introduce...

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Identifiers

PMID: 29220677
DOI: 10.1016/j.ajhg.2017.11.001
PMCID: PMC5812911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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