Article

A powerful approach to estimating annotation-stratified genetic covariance using GWAS summary statistics

2017-03-07

Abstract excerpt

Despite the success of large-scale genome-wide association studies (GWASs) on complex traits, our understanding of their genetic architecture is far from complete. Jointly modeling multiple traits’ genetic profiles has provided insights into the shared genetic basis of many complex traits. However, large-scale inference sets a high bar for both statistical power and biological interpretability. Here we introduce a...

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Literature Corpus work: 56018513-4778-5494-aff7-c6d1806dc0db
DOI: 10.1101/114561

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