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Integrative multi-omics identifies regulatory and exhausted T cell types and novel immunotherapy targets in CLL lymph nodes

2024-03-29

Abstract excerpt

<title>Abstract</title> <p>Failure of immunotherapy after applying checkpoint inhibitors or CAR-T cells is linked to T cell exhaustion. Here, we explored the T cell landscape in chronic lymphocytic leukemia (CLL) using blood, bone marrow and lymph node samples of patients and spleen samples of a CLL mouse model. By single-cell RNA-sequencing, mass cytometry (CyTOF), and multiplex image analysis of tissue microarr...

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Literature Corpus work
989d5736-16b4-523d-840b-0bc444fe355f
DOI
10.21203/rs.3.rs-3909204/v1
Open publication

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Integrative multi-omics identifies regulatory and exhausted T cell types and novel immunotherapy targets in CLL lymph nodesDOI 10.21203/rs.3.rs-3909204/v1
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