Genomic profiling reveals molecular heterogeneity in patients with Richter transformation (RT) and chronic lymphocytic leukemia (CLL)

Abstract excerpt

Richter transformation (RT) represents the development of an aggressive lymphoma in chronic lymphocytic leukemia (CLL). Patients with RT and relapsed CLL have poor outcomes. Yet, the extent of molecular differences between the two entities has not been fully explored. In this pilot study, we conducted RNA-seq and targeted panel sequencing of nodal tissues from 12 patients, including seven with RT and five with CLL...

Topics

Open a Topic to create a Post that cites this publication.

• B-Lymphocytes
• Gene Expression Profiling
• Gene Expression Regulation, Neoplastic
• High-Throughput Nucleotide Sequencing
• Immunoglobulin Variable Region
• Leukemia, Lymphocytic, Chronic, B-Cell
• Ribosomes
• Spliceosomes

Identifiers and source

Literature Corpus work

57ea44e0-7abe-5f63-bc9f-5dce502c9f02

DOI

10.1101/2025.03.15.25324025