Article

Unraveling the intercellular communication disruption and key pathways in Alzheimer's disease: An integrative study of single-nucleus transcriptomes and genetic association

2023-09-12

Abstract excerpt

<title>Abstract</title><p>Background Recently, single-nucleus RNA-seq (snRNA-seq) analyses have revealed important cellular and functional features of Alzheimer's disease (AD), a prevalent neurodegenerative disease. However, our knowledge regarding intercellular communication mediated by dysregulated ligand-receptor (LR) interactions remains very limited in AD brains. Methods We systematically assessed the interce...

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Literature Corpus work: 9898daf4-e8ac-511f-bb4d-df0a75fc6436
DOI: 10.21203/rs.3.rs-3335643/v1

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