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Mediator Kinase Inhibition Impedes Transcriptional Plasticity and Prevents Resistance to ERK/MAPK-Targeted Therapy in <i>KRAS</i> -Mutant Cancers

2022-09-18

Abstract excerpt

Acquired resistance remains a major challenge for therapies targeting oncogene activated pathways. KRAS is the most frequently mutated oncogene in human cancers, yet strategies targeting its downstream signaling kinases have failed to produce durable treatment responses. Here, we developed multiple models of acquired resistance to dual-mechanism ERK/MAPK inhibitors across KRAS -mutant pancreatic, colorectal, and...

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Literature Corpus work
a3bdc2cc-2ab8-5e76-bb27-e57b91232821
DOI
10.1101/2022.09.17.508384
Open publication

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Mediator Kinase Inhibition Impedes Transcriptional Plasticity and Prevents Resistance to ERK/MAPK-Targeted Therapy in <i>KRAS</i> -Mutant CancersDOI 10.1101/2022.09.17.508384
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