Article

Phosphorylation of Pit-1 by Cyclin-Dependent Kinase 5 at Serine 126 is Associated with Cell Proliferation and Poor Prognosis in Prolactinomas

2020-06-29

Abstract excerpt

<title>Abstract</title> <p><bold>Background </bold>Pit-1 is a POU-homeodomain transcription factor, and cyclin-dependent kinase 5 (CDK5) is a protein kinase that can phosphorylate many key transcription factors, but the mechanism by which CDK5 phosphorylates Pit-1 is unclear.<bold>Methods</bold> We generated an antibody that specifically recognizes phosphorylated the serine at position 126 of Pit-1 (Ser126-Pit-1)...

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Literature Corpus work: 9862d197-7b1e-59dc-8bd7-63fa5a1dfbd0
DOI: 10.21203/rs.3.rs-37031/v1

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