Article

Phosphorylation of Pit-1 by Cyclin-dependent Kinase 5 at Serine 126 is Associated With Cell Proliferation and Poor Prognosis in Prolactinomas

2020-08-11

Abstract excerpt

<title>Abstract</title> <p><bold>Background：</bold>Pit-1 is a POU-homeodomain transcription factor, Cyclin-dependent kinase（CDK5）is a protein kinase that can phosphorylate many key transcription factors, but the mechanism of CDK5 phosphorylates Pit-1 is unclear.<bold>Methods:</bold> We generated an antibody that specifically recognizes phosphorylated serine at position 126 of Pit-1 (Ser126-Pit-1); we used western...

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Literature Corpus work: 2c42fd40-de62-5cfe-8ab5-3ef889ca823e
DOI: 10.21203/rs.3.rs-56095/v1

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